The LW blood group system: a review.
نویسنده
چکیده
The Rh blood group system is one of the most polymorphic and immunogenic systems known in humans. In the past decade, intense investigation has yielded considerable knowledge of the molecular background of this system. The genes encoding 2 distinct Rh proteins that carry C or c together with either E or e antigens, and the D antigen, have been cloned, and the molecular bases of many of the antigens and of the phenotypes have been determined. A related protein, the Rh glycoprotein is essential for assembly of the Rh protein complex in the erythrocyte membrane and for expression of Rh antigens. The purpose of this review is to provide an overview of several aspects of the Rh blood group system, including the confusing terminology, progress in molecular understanding, and how this developing knowledge can be used in the clinical setting. Extensive documentation is provided to enable the interested reader to obtain further information. (Blood. 2000;95:375-387)
منابع مشابه
Identification and partial characterization of the human erythrocyte membrane component(s) that express the antigens of the LW blood-group system.
Rhnull human erythrocytes lack the antigens of the Rhesus blood-group system, have an abnormal shape, have an increased osmotic fragility, and are associated with mild chronic haemolytic anaemia. Rhnull erythrocytes also lack all antigens of the LW blood-group system, but the functional significance of this deficiency is unknown. We have identified, by immunoblotting with two mouse monoclonal a...
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متن کاملCharacterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes.
The LW blood group is carried by a 42-kD glycoprotein that belongs to the family of intercellular adhesion molecules. The LW gene is organized into three exons spanning an HindIII fragment of approximately 2.65 kb. The exon/intron architecture correlates to the structural domains of the protein and resembles that of other Ig superfamily members except that the signal peptide and the first Ig-li...
متن کاملThe LW blood group glycoprotein is homologous to intercellular adhesion molecules.
The LW blood group antigens reside on a 42-kDa erythrocyte membrane glycoprotein that was purified by immunoaffinity and partially sequenced. From this information, a specific PCR-amplified DNA fragment was used to screen a lambda gt11 human bone marrow cDNA library. Two forms of cDNA were isolated; the first encoded a single spanning transmembrane protein of 270 amino acids, including a 29-ami...
متن کاملDo not confuse anti-LW autoantibodies with anti-D
DOI: 10.5581/1516-8484.20130042 Even though the anti-LW antibody has little clinical importance, the present report aims at demonstrating that one must be careful about its possible identification. The weak anti-LW may be confused with anti-D autoor allo-antibodies and differentiating them is important particularly in women during the fertile period, and in RhDpregnant women, due to the possibi...
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عنوان ژورنال:
- Immunohematology
دوره 27 4 شماره
صفحات -
تاریخ انتشار 1998